Bench to Bedside | December 2016/January 2017

A Look Back at 2016: A Banner Year for Pediatric Research at CHOP

As we look ahead to a new year and new opportunities in 2017, it’s worth first taking a look back at how much we achieved in 2016. It was a busy year, and investigators from Children’s Hospital of Philadelphia made remarkable progress and reached major milestones of discovery to aid children’s health. These achievements are too numerous to mention in a single roundup, so this review will not be comprehensive. Even so, these highlights of stories we brought you over the course of 2016 in Bench to Bedside should give a good taste of where we’ve been — and whet your appetites for what’s to come.

New Research Initiatives Launch

The past year saw the launch of several new research initiatives at CHOP. In January, the Center for Data-Driven Discovery in Biomedicine was announced, and in November we brought you the latest updates on its major data-sharing platform, CAVATICA. Two new Research Affinity Groups also began, focused on mHealth (health research using mobile and digital tools) and on global health. And in the fall, CHOP announced the new $50 million Roberts Collaborative for Genetics and Individualized Medicine.

Childhood Cancer Advances

Childhood cancers are among the most critical and devastating diseases that researchers at CHOP are working to address. CHOP was honored to host the Coalition Against Childhood Cancer for its summit and annual meeting over the summer, while CHOP researchers have worked on continuous advances against cancer at multiple levels including molecular, technological, and national leadership. Some of the highlights include:

Molecular Secrets Unlocked

The “bench” aspect of bench-to-bedside research is critically important for understanding mechanisms of disease at a molecular level and pioneering new treatments that act on these mechanisms. CHOP had more than its fair share of exciting basic science discoveries in 2016 — and many had clear connections to future translation into therapies. CHOP researchers found an epigenetic mechanism that connects cancer cell growth with cancer cell proliferation that might apply to numerous cancer cell types. Another team discovered an RNA molecule that might play a critical role in the body’s inflammatory responses in multiple diseases. Other immunology research uncovered a mechanism by which viruses can trick the immune system and take over its machinery, which gives new insight into how that machinery works in the first place. And another team described an important molecular interaction in the braking system that the body uses to prevent an allergic or autoimmune response.

Enhancing Child, Caregiver, and Pediatrician Relationships

At the opposite end of the bench-to-bedside research spectrum, investigators at CHOP are also deeply invested in improving care for patients. Several studies in 2016 show how CHOP researchers and clinicians are doing so by enhancing relationships among pediatric providers, parents or other caregivers, and children, to support children’s health together. Some highlights:

Research Partnerships with Education, Government, and Large Systems

To truly make an impact on children’s health, no single pediatric hospital can go it alone. Researchers at CHOP have embraced this principle and worked in partnership with schools, government agencies, and large healthcare systems to reach children wherever they may need assistance to thrive in full health.

In schools, for example, CHOP researchers are partnering to improve behavioral health services for students and to collaboratively create and test behavioral interventions to help children develop healthy relationship skills. They are also partnering with teachers and students on creative ways to improve education in cardiopulmonary resuscitation (CPR) to improve the health of entire communities.

Other CHOP research on CPR in the hospital is tied into larger healthcare systems so that innovations developed in critical care here can save lives across the country and around the world. Likewise, innovative projects in pediatric medical trauma systems and in psychological trauma-informed care are connected to opportunities for systemic improvement through the healthcare system and through policymakers. CHOP researchers also worked closely with policymakers to improve care for vulnerable children who receive prescriptions for psychotropic medications that may be unwarranted.

Mitochondrial Mysteries

CHOP is a powerful hub for research on the power plants of the cell, the mitochondria. Efforts in the Center for Mitochondrial and Epigenomic Medicine, the Mitochondrial Disease Clinical Center, and across other collaborating specialties, are converging on deeper understanding of how energy production in mitochondria relates to a wide range of diseases and conditions, as well as new approaches to treating conditions known to be connected to mitochondria. Among the highlights this year:

Technological Innovation

The promise of new technology is often exciting, and it is certainly so in pediatric research. In addition to highlighting the launch of the CHOP mHealth Research Affinity Group, we also shared several stories about mHealth projects in a June special issue of Bench to Bedside: CHOP researchers are using social media tools to improve HIV prevention and care for teenagers, using a mobile app to collect data about babies’ sleep patterns, connecting young adult survivors of childhood cancer with continued care, and using digital tools with incentives to improve teens’ control over diabetes.

New technologies infuse many other areas of research, too. The advent of lymphatic imaging technologies is one area where CHOP and Penn researchers have made remarkable strides in both understanding and treating an underappreciated organ system. Elsewhere at CHOP, researchers are developing imaging tools to understand the placenta, testing ways to speed blood vessel repair with magnetism, developing computer-vision technologies to quantify dermatological assessments, and creating tools to link pediatric care with public health systems.

What innovations will 2017 bring? Stay with us to find out, and get a preview in our look ahead!


www.research.chop.edu

Produced by The Children’s Hospital of Philadelphia Research Institute.

© 2017 by The Children’s Hospital of Philadelphia, All Rights Reserved.