April 2015

“With nearly 80 percent of pediatric practices now capturing data in EHRs, a remarkable opportunity exists to use these data to improve health outcomes.”- Alexander G. Fiks, MD, MSCE

New Research Center to Tackle Pediatric Health Disparities

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Though clinicians are tasked with doing their very best to extend the same level of care to all patients, the fact remains that disparities exist in care and health outcomes, especially in pediatric patients. A new center at The Children’s Hospital of Philadelphia Research Institute …

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Genomic Sequencing Helps Scientists Trace Leukemia Relapse

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The ability to sequence all the genetic abnormalities in a tumor cell was unimaginable when Stephen Hunger, MD, was a pediatric oncology fellow. Twenty-five years later, he and a team of researchers from throughout the country used highly sensitive deep sequencing techniques to see how …

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Shared Decision-Making Portal Shown to Improve Asthma Care

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A quick search for the term “shared decision making” on PubMed shows an interesting progression. The term first appears in the title of a 1968 paper on education, and then in five papers in the 1970s. Likewise, it appears in only two papers in the …

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A Tireless Advocate for Adolescent Girls’ Health

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Adolescent gynecologist Aletha Y. Akers, MD, MPH, is a busy woman. Still relatively new to The Children’s Hospital of Philadelphia, Dr. Akers has already tackled her many responsibilities with aplomb: launching Children’s Hospital’s new adolescent gynecological consult service; seeing patients in the clinic; and leading …

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New Guideline Curbs Overuse of Antibiotics for Tonsillectomies

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Antimicrobial resistance is spreading around the world, hampering physicians’ capacity for treating bacterial infections swiftly and reliably. Partly to blame is clinical overuse of antibiotics, so researchers are examining ways that clinicians can change or improve their antibiotic stewardship practices. For example, the American Academy …

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PolicyLab Study Shows Antipsychotics Can Increase Diabetes Risk

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Researchers from The Children’s Hospital of Philadelphia’s PolicyLab recently published the largest study to date documenting the significant risks to children’s health associated with prescription antipsychotics, a powerful a class of medications used to treat mental and behavioral health disorders. The results, which were published …

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Neuroblastoma Studies Show Promise of Nanoparticles in Fighting Tumors

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Delving into the world of the extremely small, researchers from The Children’s Hospital of Philadelphia are exploring how biodegradable nanoparticles can precisely deliver anticancer drugs to attack neuroblastoma, an often-deadly children’s cancer. By bringing together experts in pediatric oncology with experts in nanotechnology, Children’s Hospital …

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Restoring Cellular Energy Could Lead to Mitochondrial Disease Treatments

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Rooted in malfunctions in the power plants that energize our cells, mitochondrial disorders are notoriously complex, with few effective treatments. Now, novel findings may hold great promise for children and adults with mitochondrial disorders. By using existing human drugs to improve metabolism and restore shortened …

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Blood Investigation Bolsters Mutant Protein in Hemophilia Therapy

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Using gene therapy to produce a mutant human protein with unusually high blood-clotting power, scientists have successfully treated dogs with the bleeding disorder hemophilia, without triggering an unwanted immune response. In addition, the “turbocharged” clotting factor protein eliminated pre-existing antibodies that often weaken conventional treatments …

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The Brain is Important: CHOP Expert Talks Pseudotumor Cerebri Syndrome

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The work of Children’s Hospital’s Shana E. McCormack, MD, was recently featured on Pediatric Research’s “Pediapod” podcast. Dr. McCormack spoke to host Charlotte Stoddart about her review of pseudotumor cerebri syndrome, also known as false brain tumor, in which patients experience the symptoms of a …

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Pilot Grant to Support Eosinophilic Esophagitis Investigation

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The Children’s Hospital of Philadelphia’s Antonella Cianferoni, MD, PhD, recently received a two-year, $140,000 grant from the American Partnership for Eosinophilic Disorders (APFED) and the Allergy, Asthma & Immunology Education and Research Organization (ARTrust) to study the genetic underpinnings of the severe food allergy eosinophilic …

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CHOP, Drexel, Hebrew University Partnership Honored

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The Philadelphia-Israel Chamber of Commerce (PICC) recently honored the joint research collaboration among Drexel University, The Children’s Hospital of Philadelphia (CHOP), and the Hebrew University of Jerusalem with the 2015 Yitzhak Rabin Public Service Award. The Rabin Award honors regional businesses, academic institutions, and their leaders …

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