December 2014

“Our results show that these engineered ‘hunter’ cells greatly expand in patients, producing very high complete response rates that then persist in patients, potentially allowing for long-term disease control.”- Stephan A. Grupp, MD, PhD

Affordable Care Act Leaves Many Children Without Benefits


An article published in the December issue of Health Affairs is the first comprehensive analysis to investigate the Affordable Care Act’s (ACA) Essential Health Benefit (EHB) as it relates to children. The study found the EHB has resulted in a state-by-state patchwork of coverage for …

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Benefits Persist in T Cell Therapy for Children with Relapsed Leukemia


Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and the most common childhood leukemia. Some patients with ALL have a highly aggressive form of the disease, one that causes either the cancer to recur or is resistant from the start to …

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Oral, Intravenous Antibiotics Equally Effective at Treating Bone Infection


The Children’s Hospital of Philadelphia’s (CHOP) Ron Keren, MD, MPH, was the first author of a study published recently in JAMA Pediatrics that showed treating osteomyelitis with oral antibiotics did not result in more treatment failures than treatment with intravenous antibiotics. As a result, the …

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Study Questions Packing Children’s Lunches


To pack a lunch or not to pack a lunch: that is every parent’s question. A study recently published in JAMA Pediatrics may supply some answers to the age-old question of what to do about your children’s lunch. Baylor College of Medicine’s Karen Weber Cullen, …

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Genetic Clues Found in Food Allergy Eosinophilic Esophagitis


Scientists have identified four new genes associated with the severe food allergy eosinophilic esophagitis (EoE). Because the genes appear to have roles in other allergic diseases and in inflammation, the findings may point toward potential new treatments for EoE. “This research adds to the evidence …

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Researchers Study Factors That May Complicate Concussion Recovery


Recognition and diagnosis of concussions have exploded over the past decade, mainly due to increased media attention on how professional sports teams deal with these serious injuries. Nearly 173,000 children and adolescents are seen in emergency departments annually for sports- and recreation-related traumatic brain injuries …

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Transparent Microelectrodes Allow for Dynamic Imaging to Study Epilepsy


The brain is the body’s control center, and it relies on an intricate circuitry of thousands of neurons that communicate with each other through electrical and chemical signals. An electroencephalogram (EEG), which is a recording of brain activity using small button electrodes, helps neuroscience researchers …

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CHOP Expert Contributes to Resident Hour, Colon Cancer Studies


The Children’s Hospital of Philadelphia’s Jeffrey H. Silber, MD, PhD, contributed to two recent studies that span the research spectrum. The first, published in The Journal of the American Medical Association (JAMA), investigated changes to the number of hours medical residents can work. The second …

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Lessons Learned From OB Unit Closures: Planning, Communication Needed


Hospital staff of obstetric (OB) units are dedicated to ensuring that an infant’s birth is a moment of wonder and joy, but after a series of hospitals in Philadelphia began closing their maternity programs, the OB units that remained open were strained by surges in …

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