July 2015

“Now that we know that sequencing these resistant cancers can nominate novel therapies, we think we are entering a new era of personalized therapeutic decision making for children with currently incurable disease.”- John Maris, MD

Researchers Pinpoint Mutations in Relapsed Neuroblastoma

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An international collaboration of researchers has identified several progressive series of mutations that occur in tumor cells responsible for aggressive subsets of neuroblastoma that relapse after chemotherapy. Neuroblastoma, a solid tumor of nerve tissue, is the most common cancer in infants, and its cure rates …

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National Network Leverages Electronic Records to Improve Care

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In a special article recently published in Pediatrics, a research group led by The Children’s Hospital of Philadelphia’s Alexander G. Fiks, MD, MSCE, details the creation of a national “super network” devoted to comparative effectiveness research (CER). The network — the Comparative Effectiveness Research Through …

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Home Plate Study Hits the Ground Running on Healthy Food Prep

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Nearly one in three children are considered to be overweight or obese in the U.S. What these children have on their plates at home today can affect their health for tomorrow. Senbagam Virudachalam MD, MSHP, faculty member at The Children’s Hospital of Philadelphia’s PolicyLab, is …

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President Obama Appoints CHOP Oncologist to National Cancer Board

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Peter C. Adamson, MD, a pediatric oncologist and leading scientist at The Children’s Hospital of Philadelphia, and a professor of Pediatrics and Pharmacology at the Perelman School of Medicine at the University of Pennsylvania, has been appointed by President Obama to the National Cancer Advisory …

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Experts Target Mitochondrial Dysfunction After Pediatric TBI

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Pediatric traumatic brain injury (TBI) will become a major cause of death and disability of children within the next several years, The World Health Organization predicts, as many third-world countries become urbanized. Whether the injuries result from motor vehicle crashes on the road or sports …

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New Ways Needed to Predict, Treat Relapsed Leukemia

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Bench-to-bedside research at The Children’s Hospital of Philadelphia involves talented scientists who make discoveries in the lab that translate into investigations of clinical applications. CHOP experts studying T-cell acute lymphoblastic leukemia (T-ALL) are taking this model one step further — bench to bedside and back …

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Steven Douglas, MD, Honored as Paradigm Builder in HIV Neurovirology

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The way viruses can infect the nervous system is at the heart of neurovirology, an important field of study that includes not only neuroscience and virology, but also molecular biology and immunology. Steven D. Douglas, MD, chief of the Section of Immunology at The Children’s …

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Vismodegib’s Activity Tested in Medulloblastoma Subgroups

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Researchers’ understanding of the molecular pathways involved in cancer has enabled the development of targeted drugs for diseases such as pediatric and adult recurrent medulloblastoma, a type of rare brain cancer. Two studies reported in the Journal of Clinical Oncology assessed the efficacy of a …

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Young Adults Find Selecting Health Insurance Plans Confusing

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While young adults are essential to the implementation of the Affordable Care Act (ACA), the process of applying for health insurance using the federal insurance marketplace HealthCare.gov can be confusing to them, according to a small, observational study. Historically, a significant part of the young …

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