March 2015

“New advances in surgery occur frequently, but only the test of time can show their true worth at long term follow-up. The VEPTR techniques appear to be living up to their promise.”- Robert M. Campbell, MD

Giving Children Room to Breathe


Named after the Titans — a group of powerful Ancient Greek gods — the element titanium is known for its strength and resistance to corrosion. Titanium and titanium alloys are used in a wide variety of applications, from the mundane, such as in house paint, …

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Finding New Genetic Syndrome Ends Medical Odyssey


At 3 foot 8 inches, 66 pounds, Leta Moseley is a tiny teenager with a big personality. Seventeen years ago, her family embarked on a medical odyssey in search of a diagnosis for Leta, who has cognitive disabilities, speaks only a few words, and has …

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CHOP Advocate Dr. Paul Offit Speaks Out for Measles Vaccine


Including noting the “science of vaccines is clear” in a Jewish Exponent article, The Children’s Hospital of Philadelphia physician and Vaccine Education Center Director Paul A. Offit, MD, spoke to a number of media outlets about the recent measles outbreaks and the vaccine worries the …

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Study Shows Babies’ BMI May Predict Childhood Obesity


A recent Journal of Clinical Endicronology and Metabolism study shows body mass index (BMI) during infancy may help to predict if a child will be obese by age four. In work focused on the infant BMI-childhood obesity relationship in a cohort with a majority of …

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Severe Pediatric Sepsis Remains Prevalent Public Health Problem


Severe pediatric sepsis is a formidable challenge for critical care specialists who unfortunately see children in pediatric intensive care units (PICUs) die from body-wide inflammation and subsequent organ damage that can occur when the immune system responds to infection. Until recently, researchers had not defined …

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Rare Disease Study Reveals Gene Crucial to Immune Defense


Genomics researchers from the Center for Applied Genomics (CAG) at The Children’s Hospital of Philadelphia investigating a serious, rare disease called common variable immunodeficiency (CVID) have discovered a gene linked to immune defense. Children with the challenging disorder have difficulty fighting off infections. CVID affects …

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Using Virtual Visits to Help Families Transition to Home


Clinicians at The Children’s Hospital of Philadelphia care for patients with complex medical and surgical conditions, and many rely on sophisticated technology long after they return home. The initial transition from hospital to home can be a daunting time for parents, as they take charge …

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NTRK3 Gene Mutation Could Contribute to Heart Defects


During pregnancy, a series of intricate processes takes place for the heart to form correctly. Cells develop, proliferate, migrate, and die frequently, as the heart tissue transforms from a primary heart tube to four cardiac chambers. Scientists suspect that if there is a genetic mishap, …

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Peer Review Simulation Sheds Light on Bias in Grant Funding


In an ideal world, the very best grant proposals that are the most likely to advance scientific discovery would win financial support from the National Institutes of Health (NIH). But the reality is that science is not immune to human bias. Race, ethnicity, gender, career …

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Institute Recognizes Outstanding Young Investigators


The Children’s Hospital of Philadelphia Research Institute has a robust training program for researchers at multiple levels, including CHOP-based graduate students, postdoctoral fellows and physician fellows. During CHOP Research’s recent Poster Day event, the Institute took time to recognize notable advanced research trainees without whom …

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CIRP Engineering Students Honored During Poster Day


Two undergraduate engineers from the Center for Injury Research and Prevention (CIRP) were recently honored during CHOP Research Poster Day. Held February 25, 2015 Poster Day was the 25th anniversary of the event, and 40 researchers’ work was selected by panel of faculty judges to …

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NIH Support Boosts Transformative Summer Program


An innovative summer program at The Children’s Hospital of Philadelphia Research Institute that exposes undergraduates to CHOP laboratories has received key backing from the National Institutes of Health. CHOP Research was awarded more than $500,000 from the Eunice Kennedy Shriver National Institute of Child Health …

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