March 2016

“This is by far the biggest pediatric biobank in the world. No one has anything remotely close to what we have built here at CHOP.”- Hakon Hakonarson, MD, PhD

CPR for Children Gets Smarter

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Heart-stopping. Critical moment. Life-or-death. The catchphrases that have come to define powerful dramatic scenes have real-life antecedents in pediatric intensive care units (PICUs), where sick children are at the highest risk of cardiac arrest in the hospital. More than half of children who experience cardiac …

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Intergenerational Family Services: Serving Caregivers, Improving Child Health

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As a practicing pediatrician, David Rubin, MD, MSCE, saw firsthand how parents and guardians often were dealing with myriad issues that lessened his ability to help their children. Families would not fill prescriptions due to financial hardships, for example, or a parent with emotional disturbances …

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Seeing the Impact of a Decade of Genomics Discoveries

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When The Children’s Hospital of Philadelphia established the Center for Applied Genomics (CAG) in 2006 with a $40 million commitment, it was one of the largest single investments in a research program at the hospital’s history. The ambitious idea spearheaded by CAG’s founder and director, …

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A Molecular Balancing Act to Fight Autoimmune Disease and Cancer

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Wayne Hancock, MBBS, PhD, has spent more than a decade trying to strengthen the activity of certain cells in the body that could help control conditions including autoimmune diseases and organ transplant rejection. When his efforts inadvertently weakened those cells, he used to throw those …

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Concussions’ Unpredictability Underscores Need for Follow-Up Care

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Concussions do not come with easy answers. Michael Nance, MD, director of the pediatric trauma program at The Children’s Hospital of Philadelphia, recently reinforced that lesson with research looking for simple tests to guide follow-up care for youth who come to the emergency department (ED) …

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Using Doctors’ Certification Requirements to Increase HPV Vaccination

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Children’s health outcomes can improve, and pediatricians can be satisfied with the process, when the doctors participate in quality-improvement (QI) programs that are required to maintain their board certification. Researchers at The Children’s Hospital of Philadelphia demonstrated such success with a low-cost program designed to …

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Researchers Examine Obesity, Cardiovascular Risks in Down Syndrome

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Children with Down syndrome (also known as Trisomy 21) are prone to obesity. Their families may be concerned about their future risks for cardiovascular problems as well as their quality of life. Although Down syndrome is the most common chromosomal anomaly in humans, affecting about …

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In the Neighborhood: Environmental Features Associated With Teen Homicide

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It is not a pretty picture. Boarded up, dilapidated buildings. Overgrown vacant lots filled with debris. Security bars on homes and businesses. A landscape of disorder surrounds many urban youth who are at higher risk of homicide. A new study took a close look at …

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