November 2015

“More frequently than previously thought, children with cancer may have genes predisposing them to cancer, even when cancer doesn’t show up in the child’s family history. We need to better understand how other genes may interact with the original mutation to cause cancer in the child.”- John M. Maris, pediatric oncologist, Giulio D’Angio Chair in Neuroblastoma Research

Researchers Reveal How B-ALL Leukemia Tumors Resist Immunotherapy


Leukemia tumors are cleverly deceptive, but researchers at The Children’s Hospital of Philadelphia have figured out one of their tricks that allows cancer cells to be invisible to chimeric antigen receptor-armed T cells (CTL019), a new form of investigational immunotherapy. In recent years, CTL019 therapy …

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Drugs May Be What’s the Matter With White Matter in HIV


Some of the neurological and psychiatric complications associated with HIV may be side effects of the medications that control the virus, and not caused by the virus itself, according to a new study from researchers at The Children’s Hospital of Philadelphia and the University of …

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Targeted Gene Therapy Aimed at Devastating Childhood Disease


When something important is missing, we often search for a replacement. After many years of looking, a team of researchers at The Children’s Hospital of Philadelphia and the University of Missouri have found a way to substitute for a missing gene linked to a relentless …

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Girls in Families With Breast Cancer Risk Well-Adjusted


The thought of getting breast cancer can be a worrisome one, and it may be on the minds of young girls more than ever before, as knowledge about family and genetic risk has increased in the recent decade. The LEGACY Girls Study, a study taking …

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Studying the Brain’s Fundamental Drum Beat to Understand Autism


A drum beat coordinating brain activity and thus organizing the music of life emerges from deep inside the human brain. This electromagnetic neural pulse —eight to 12 beats per second — is known as the resting-state alpha rhythm. “Alpha rhythms may be the most fundamental …

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Educational Intervention Decreases Mean Girls’ Relational Aggression


The “Mean Girls” phenomenon is not just the subject of fiction. Relational aggression, such as using gossip and social exclusion to harm others, is all too common among preadolescent and adolescent girls. A new study from The Children’s Hospital of Philadelphia suggests that educational interventions …

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Study Gives New Insights Into Genetic Predisposition to Neuroblastoma


Pediatric oncology researchers have narrowed down a culprit in an aggressive form of the childhood cancer neuroblastoma that makes the disease progress once tumors form. By mapping how DNA interacts with regulatory proteins that control transcription, part of the process by which DNA-encoded information carries …

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Stroke Rehabilitation Research Connects Brain to Gait


If you have ever hit your stride on a moving walkway, the type commonly found in airports, consider how it felt when you stepped back onto solid ground. You may have felt a sudden but brief discombobulation while your brain worked to correct its temporary …

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New CHOP Study to Understand Risk of Hospital Readmission


One in 20 infants is admitted to the hospital during the first year of life. As frightening as it may be for families to have a child whose health condition requires hospitalization, in too many cases the experience gets worse when a relapse or problem …

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