October 2015

“CHOP has always been a leader in research, a place full of people generating ideas that improve health. Now what we’re trying to do is build on that strength with the entrepreneurial skill set to bring those ideas to market in a faster and more commercially focused way.”- Patrick FitzGerald

Driving Safety Research Accelerates Into Business


If you do not expect pediatric research to have anything to do with improving the bottom line of a parcel delivery service or cable company, then the story of Diagnostic Driving may surprise you. Diagnostic Driving, a startup company spun out from The Children’s Hospital …

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New Growth Charts for Down Syndrome a Tall Order


Pediatricians have long known that children with Down syndrome grow differently than typical children, but the last growth charts for children with Down syndrome were developed almost 30 years ago. Since that time, clinical care for children with Down syndrome, especially early in life, has …

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Cornering a Cancer-Connected Autoimmune Disease


It is certainly not good news for children to get a double whammy of both cancer and autoimmune disease. Unfortunately, for a small subset of children with neuroblastoma, a common childhood cancer of the peripheral nervous system, an extremely rare autoimmune disorder called Opsoclonus Myoclonus Ataxia …

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Research Institute’s Bryan Wolf, MD, PhD, New to Pennsylvania Bio Board


The Children’s Hospital of Philadelphia Research Institute is among 2,300 life sciences establishments that call Pennsylvania home. As a newly appointed member of Pennsylvania Bio’s Board of Directors, Bryan Wolf, MD, PhD, Chief Scientific Officer of the Research Institute, will foster supportive relationships within this …

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Drug Trial Shows “Profound” Success Treating Rare Blood Disorders


When the immune system inappropriately destroys blood cells, in a relatively rare group of diseases called autoimmune cytopenias, children may suffer for years with anemia, uncontrolled bleeding, and vulnerability to infections, while their parents struggle to find a diagnosis. Once diagnosed, even the standard treatment …

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On the Trail of a Cancer Predisposition Syndrome


Inside the cells of a developing human embryo is a little piece of “Alice in Wonderland.” While most of our bodies’ genes are expressed from both our mothers’ and fathers’ chromosomes, there is a particular growth-regulating region of chromosome 11 where Dad’s genes make you …

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CHOP-led Consortium Focuses on Patient-Reported Outcomes


“How tired do you feel?” a doctor asks a child with a chronic disease. Or, “How well are you managing stress?” The answers to questions like these are even more important, from many patients’ and families’ perspectives, than the particular numerical result of their lab …

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Infant Brain Imaging Study Finds Early Differences in Autism Symptom Domains


Subtle signs of autism spectrum disorder (ASD) are evident much earlier than previously thought, according to a landmark study conducted by the Infant Brain Imaging Study (IBIS), a large, multisite research collaboration that includes the Center for Autism Research (CAR) at The Children’s Hospital of …

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Researchers Debunk Claim that Vaccines Cause Retinal Bleeding in Children


Most of the time, we associate research with laboratories and test tubes, not courtrooms and gavels. Yet, studies that build scientific evidence can influence our legal system in important ways. Clinician researchers at The Children’s Hospital of Philadelphia, for instance, recently conducted a study that …

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