September 2015

“We have established the largest pediatric biobank in the world, and by coupling the genotyping and sequencing data we have produced from these samples with medical information from the electronic health records from CHOP and other eMERGE sites, we have the ability to identify the most effective therapies for our patients as we move forward in the era of precision medicine.”- Hakon Hakonarson, MD, PhD

eMERGE Network Looks at How to Provide DNA Test Results, Improve Care


Sometimes the tiniest shift inherited in your DNA code can have tremendous ripple effects on your health and treatment choices. A new $3.6 million grant from the National Institutes of Health’s Electronic Medical Records and Genomics (eMERGE) program will allow scientists at The Children’s Hospital …

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New Research Consortium Aims to Identify Drugs for Pediatric Cancers


The Children’s Hospital of Philadelphia and four other high-profile oncology research programs plus a coordinating center joined the new Pediatric Preclinical Testing Consortium (PPTC) launched by the National Cancer Institute (NCI) to help researchers identify drug candidates for pediatric clinical trials. The centers will focus …

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Focus on Vision and Balance Deficits Following Youth Concussion


Recognizing a concussion oftentimes is not crystal clear for clinicians. A young patient with a head injury may report experiencing common concussion symptoms, and yet results from a standard physical exam seem normal. Findings from two new research studies suggest that additional assessments of a …

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MOMS Study Suggests Candidates, Timing for Fetal Spina Bifida Surgery


Fetal spina bifida surgery to repair myelomeningocele is a remarkable and intricate procedure performed before birth. If untreated, spinal cord damage from amniotic fluid exposure is progressive during gestation. Highly skilled surgeons close a gap in the fetus’ spine that allows a portion of the …

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Vs. Cancer and CBTTC a Winning Team for Childhood Brain Tumor Research


From pitchers and catchers to fast base runners and big hitters, baseball rosters need a diverse range of skills, but to achieve victory, individual players need to work together. Such dedication to collaboration also is a winning game plan when patients, clinicians, researchers, and donors …

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Expanding Clinical Teams’ Communication Skills When Sharing Care Plans


It can be incredibly distressing for a family dealing with a serious or life-threatening illness to receive mixed messages from the clinical team about their child’s prognosis or care plan. The roots of this miscommunication may begin way before they must make an important treatment …

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Missing Well Visits Results in Preventive Care Gaps for Preterm Infants


Newborns’ first big journeys into the world often are to well-baby exams at pediatricians offices. These checkups usually are scheduled within the first days or weeks after discharge from the hospital, followed by exams every few months during their first year of life. Well visits …

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Teaching the Immune System to Have Long-term Memory for Leukemia


Your immune system is designed to protect against foreign invaders such as infections, but you may not realize that it also destroys abnormal cells that your body produces. Researchers suggest that some types of cancer cells, such as acute lymphoblastic childhood leukemia (ALL) that recurs …

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Pediatric Imaging Techniques Shifting Away From Computerized Tomography


Children’s hospitals are shifting away from imaging techniques that use ionizing radiation and moving toward alternatives that do not pose potential hazards. Accumulating evidence suggests that high dosages of ionizing radiation used in computerized tomography (CT) scans is linked to increased cancer risk. Researchers from …

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