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Image of Dr. Marni Falk

Modernizing Mitochondrial Medicine to Improve Patient Experience

Fifteen years ago, most clinicians hadn’t heard of mitochondrial disease: Inherited dysfunction in our body’s miniscule cellular batteries can wreak chaos in different organs...

Image of Dr. William Fox

Air Alternative? Researchers Study Liquid Ventilation for Premature Infants

For premature babies born at extremely low birth weights, severe chronic lung disease – also known as bronchopulmonary dysplasia – remains a major source of mortality and morbidity...

Image of Dr. Ian Jacobs

Clearing the Airways for Research Into Respiratory Health

From the nostrils down to the larynx, the airways of a child’s respiratory system form a fragile but fundamental area for breathing, swallowing, and speaking. Airway disorders can...


Frontiers are wild, exciting, adventurous, and bold – the places where explorers make discoveries that propel us to the future. When it comes to rare and complex diseases in children, the frontier of science is right where we want to be. In this special issue of Bench to Bedside, meet the three new Frontier Programs designated by Children’s Hospital of Philadelphia to take the cutting-edge research pioneered in their labs and clinics on a fast track to the bedside: the Mitochondrial Medicine Center, the Newborn and Infant Chronic Lung Disease Program, and the Center for Pediatric Airways Disorders.

Image of Dr. Flaura Winston
From the rise of email to the digitization of health records, Flaura Winston, MD, PhD, has watched technology transform the way we treat and manage children’s health throughout her career. And in her nearly 30 years at Children’s Hospital of Philadelphia, the founder of the Center for...
Image of Mal child holding an empty bowl
Around seven years ago during a well visit at Children’s Hospital of Philadelphia, a 12-year-old boy told Saba Khan, MD, an attending physician at CHOP, that there was one problem she could not fix. Intrigued, Dr. Khan asked him to explain further. At first hesitant, the young man finally...
Image of female child drinking water
Gulp. We’ve all heard that drinking more water is a healthy habit, but taking steps to consistently increase fluid intake can be difficult to swallow. It’s especially challenging for children because, while the Institute of Medicine has guidelines for adequate intake of water, there are...
Image of female child getting her eyes examined
Gil Binenbaum, MD, has his sights set on advancing children’s eye care by adopting new perspectives. Whether it’s developing new ways to determine when a child needs glasses or diagnosing serious conditions that could lead to blindness, the attending surgeon in the division of...
Image of Dr. Pam Weiss
Families of sick children who come to Children’s Hospital of Philadelphia are often looking for something new. They want to learn new information, find a new drug, or try a new approach that will help them to diagnose and resolve their child’s complex conditions and rare diseases....
Image of Joshua Zigmont and a young boy in a Children's Hospital Hallway
Editor’s Note: Our clinical research coordinators at Children’s Hospital of Philadelphia are a unique professional hybrid. Part researcher, healthcare professional, data coordinator, social worker, personal coach, and travel concierge, they go above and beyond their job descriptions in...

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